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Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Identifieur interne : 002347 ( Main/Exploration ); précédent : 002346; suivant : 002348

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Auteurs : Hans Lassmann [Autriche] ; Christian Bancher [Autriche] ; Helene Breitschopf [Autriche] ; Jerzy Wegiel [États-Unis] ; Maciej Bobinski [États-Unis] ; Kurt Jellinger [Autriche] ; M. Wisniewski [États-Unis]

Source :

Acta Neuropathologica [ 0001-6322 ] ; 1995-01-01.

RBID : ISTEX:779446D0BEB7EDBECBCA319F55B66ADD2604836C

Abstract

Abstract: Loss of nerve cells is a hallmark of the pathology of Alzheimer's disease (AD), yet the patterns of cell death are unknown. By analyzing DNA fragmentation in situ we found evidence for cell death not only of nerve cells but also of oligodendrocytes and microglia in AD brains. In average, 30 times more brain cells showed DNA fragmentation in AD as compared to age-matched controls. Nuclear alterations suggestive of apoptosis were rare in degenerating cells. Even though the majority of degenerating cells were not located within amyloid deposits and did not contain neurofibrillary tangles, neurons situated within areas of amyloid deposits or affected by neurofibrillary degeneration revealed a higher risk of DNA fragmentation and death than cells not exposed to these AD changes.

Url:

https://api.istex.fr/document/779446D0BEB7EDBECBCA319F55B66ADD2604836C/fulltext/pdf

DOI: 10.1007/BF00294257

Affiliations:

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Le document en format XML

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<author><name sortKey="Bobinski, Maciej" sort="Bobinski, Maciej" uniqKey="Bobinski M" first="Maciej" last="Bobinski">Maciej Bobinski</name>
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<front><div type="abstract" xml:lang="en">Abstract: Loss of nerve cells is a hallmark of the pathology of Alzheimer's disease (AD), yet the patterns of cell death are unknown. By analyzing DNA fragmentation in situ we found evidence for cell death not only of nerve cells but also of oligodendrocytes and microglia in AD brains. In average, 30 times more brain cells showed DNA fragmentation in AD as compared to age-matched controls. Nuclear alterations suggestive of apoptosis were rare in degenerating cells. Even though the majority of degenerating cells were not located within amyloid deposits and did not contain neurofibrillary tangles, neurons situated within areas of amyloid deposits or affected by neurofibrillary degeneration revealed a higher risk of DNA fragmentation and death than cells not exposed to these AD changes.</div>
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Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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